COCKAYNE SYNDROME LINKED TO ELEVATED R-LOOPS INDUCED BY STALLED RNA POLYMERASE II DURING TRANSCRIPTION ELONGATION

Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation

Abstract Mutations in the Cockayne Syndrome group B (CSB) gene cause cancer in mice, but premature aging and severe neurodevelopmental defects in humans.CSB, a member of the SWI/SNF family of chromatin remodelers, plays diverse roles in regulating gene expression and transcription-coupled nucleotide excision repair (TC-NER); however, these function

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Chinese herbal medicine anticancer cocktail soup activates immune cells to kill colon cancer cells by regulating the gut microbiota-Th17 axis

Chinese herbal medicines are effective for treating colon cancer (CC).CC development is reportedly associated with gut microbiota dysbiosis and immune function dysregulation.Herein we explored the therapeutic effects of a Chinese herbal medicine anticancer cocktail soup (CHMACS) on mice with CC and also explored its regulatory effects Vacuum Dust B

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Zero Fluoroscopy Arrhythmias Catheter Ablation: A Trend Toward More Frequent Practice in a High-Volume Center

BackgroundAwareness of radiation exposure risks associated to interventional cardiology procedures is growing.The availability of new technologies in electrophysiology laboratories has reduced fluoroscopy usage during arrhythmias ablations.The aim of this study was to describe procedures with and without X-Rays and to assess feasibility, safety, an

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